
Dry skin is more than just an annoying problem. It can lead to discomfort, irritation, and emotional distress. While many see dry skin as a cosmetic concern, it may point toward more serious health issues, particularly chronic inflammation influenced by cytokines. Recognizing this link is vital for proper management and treatment.
Understanding Dry Skin
In dry skin, also known as xerosis, the skin loses moisture and struggles to retain hydration. This condition can show up in various forms, including flakiness, redness, itching, and tightness. Factors like environmental conditions, aging, and skin diseases contribute significantly to dry skin.
Xerosis happens when the lipid (fatty) bonds between skin cells become loose and disorganized. The synthesis of these lipids - cholesterol, free fatty acids and ceramides - decreases due to age, cold and dry conditions, or skin disease. This leads to a reduction in the effectiveness of the skin barrier, making it easier for microbes like bacteria, viruses, and fungi to penetrate the skin. It can also make conditions like eczema and psoriasis worse.
Statistics show that around 30% of adults experience dry skin, and the problem often worsens with age. Older adults are up to 50% more likely to deal with this issue. Many products promise to fix the problem, resulting in a multi-billion dollar skin care industry. Do any of these products deliver?

The Role of Cytokines in Health
Cytokines are proteins released by immune cells that help manage inflammation and immune responses. They act as communication signals that can alter the behaviour of other cells. They act as messengers, influencing the growth, activity, and behavior of various immune and blood cells. Cytokines play a vital role in both healthy immune responses and inflammatory processes, but an overproduction can lead to harmful effects.
Chronic inflammation, caused by factors such as stress, pollution, and diet, stimulates the release of certain cytokines. These proteins can lead to skin barrier dysfunction, increasing transepidermal (trans = through, epidermal = skin) water loss and worsening dry skin symptoms. Studies have shown that repairing the skin barrier can actually decrease cytokine production.
Chronic Inflammation: The Hidden Threat
Chronic inflammation has implications that go beyond skin issues. This ongoing state of inflammation can lead to significant health risks. Chronic inflammation is a major contributor to a wide range of illnesses, including autoimmune diseases like rheumatoid arthritis and lupus, cardiovascular diseases, certain cancers, and neurodegenerative diseases like Alzheimer's. It can also play a role in metabolic diseases like Type 2 diabetes, gastrointestinal issues like Crohn's disease, and lung conditions such as asthma.
It's important to note that the skin is not merely a protective layer; it is an active organ linked to the immune system. When inflammation persists, it can suggest deeper health problems that require attention. Research indicates that individuals with chronic skin conditions may be more susceptible to systemic illnesses. This connection emphasizes the need for a holistic approach to skin health.
Managing Dry Skin
Many products promise to repair your skin, hydrate it, and improve its look and feel. This is often accomplished with thick, heavy creams that sit on the skin for a prolonged period of time.
To effectively address dry skin, a variety of topical treatments are often explored. One product that stands out is Podoexpert Dry & Cracked Skin Foam. This foam is scientifically developed to tackle dry skin while addressing inflammation, a key factor in many skin issues. By using ingredients designed to hydrate, soothe, and repair the skin's barrier, this product can alleviate symptoms and enhance overall skin health.
In clinical tests, a 100% improvement in the skin's lipid barrier was noted on electron microscopy within two weeks of regular use. This product is specifically designed to mimic the skin's natural lipid bonds and stimulate autoregeneration (auto = self, regeneration = regrowth; it stimulates the body to heal itself). Further studies have shown that repairing the skin barrier significantly decreases cytokine production and therefore most likely decreases chronic inflammation. This could decrease one's risk of chronic illnesses.
Podoexpert foam products are rapidly absorbed into the skin, getting right to where they're needed. This can be demonstrated by the very low-tech "snap test." Within 30 seconds of rubbing these products into your hands, you can snap your fingers. Try that with petroleum jelly, oils, animal fats, or heavy creams! This rapid absorption also means you won't get stuck to your socks or other clothing when you put them on after application. And a little bit goes a long way. The foaming makes the container last for a few months rather than a few weeks, even with regular use.
Sole Focus uses Podoexpert products in our appointments, and has products available for home use, as well.
Practical Solutions for Dry Skin
Managing dry skin requires a well-rounded approach. Here are some practical solutions you can integrate into your daily routine:
Hydration: Ensure you drink enough water. This can be tricky, because everyone needs different amounts of water on different days. The best way to monitor your hydration is actually to watch your urine. It should be a pale yellow, not dark and not completely clear. Your thirst will also guide you. Don't feel you need to drink 2 litres per day - let your body tell you when you're getting enough water. The minimum amount of urine a healthy adult should produce is 30 mL (1 fl. oz.) per hour.
Moisturizers: Choose clinically proven moisturizers like Podoexpert Dry Skin Foam to fight dryness. That said, the best product is the one you will use regularly. No matter what you choose, if you can use it once or twice a day every day, it's the right product for you. Do not put moisturizing creams or lotions between the toes; the moisture can encourage the growth of athlete's foot.
Gentle Cleansing: Opt for mild, hydrating cleansers to preserve the skin's natural oils. Avoid prolonged soaking of the skin, especially at higher water temperatures. Showers and baths should be kept at a warm setting for no more than 5-10 minutes to prevent drying the skin. Apply your favourite skin care product immediately after bathing to help lock in the moisture.
Climate Control: Use a humidifier in dry conditions. Studies indicate that maintaining humidity levels above 30% can significantly improve skin hydration.
Balanced Diet: Include omega-3 fatty acids from fish, nuts, and seeds; vitamins A and E from fruits and vegetables; and antioxidants from berries to help combat inflammation.
Consult Experts: If your dry skin persists, visit a dermatologist to explore further treatment options.
Your Road to Healthier Skin
Dry skin can signal chronic inflammation linked to cytokine activity. By understanding the connection between skin health and overall wellness, you can adopt a
comprehensive approach to manage dry skin effectively - and improve your overall health.
Incorporating effective products like Podoexpert Dry & Cracked Skin Foam and making lifestyle changes can significantly improve your skin's condition. Taking action not only relieves the discomfort of dry skin but also addresses potential health risks associated with chronic inflammation. Prioritize your skin health today, and consider what steps you can take to enhance it for tomorrow.
References:
D Daehnhardt, S Daehnhardt-Pfeiffer, J Schulte-Walter, T Neubourg, E Hanisch, C Schmetz, M Breuer, R Fölster-Holst. The Influence of Two Different Foam Creams on Skin Barrier Repair of Foot Xerosis: A Prospective, Double-Blind, Randomised, Placebo-Controlled Intra-Individual Study. Skin Pharmacol Physiol. 2016; 29(5):266-272.
M Greger. 2023. How Not to Age. Flatiron Books, UK.
L Ye, T M Mauro, E Dang, G Wang, L Z Hu, C Yu, S Jeong, K Feingold, P M Elia, C Z Lv, M Q Man. Topical applications of an emollient reduce circulating pro-inflammatory cytokine levels in chronically aged humans: a pilot clinical study. J Eur Acad Dermatol Venereol. 2019 Nov; 33(11):2197-2201.





